YK-11

YK-11, also known as myostine, is a Selective Androgen Receptor Modulator (SARM) clinically proven to partially activate the androgen receptor while also acting as a myostatin inhibitor.

A compelling study led by researchers Lee et al. investigated YK-11 as a potential muscle-building and muscle-preserving compound under conditions of sepsis. In the experiment, mice were fed two different doses of YK-11 (orally administered at 350 mg/kg and 700 mg/kg) for ten days. The researchers then examined how these mice responded to a peritoneal injection of E. coli bacteria.

The study demonstrated that YK-11 inhibited the activity of myostatin, a hormone that limits muscle growth in mammals (source). Not only did the mice treated with YK-11 maintain their body mass during the disease phase, but they also had a more favorable fat-to-muscle ratio, indicating less fat and more lean tissue compared to the control group.

Furthermore, the results showed that the treated mice were able to recover lost muscle mass in the back and thighs following exposure to systemic E. coli. Their muscle cells also demonstrated increased resistance to atrophy when compared to those of the control group.

In addition to its impact on muscle mass, YK-11 also affected the immune response to gram-negative bacteria. The treatment with YK-11 led to reduced negative effects of bacterial infections, including a decrease in endotoxins and inflammatory markers in the lungs.

Moreover, there was a significant reduction in biomarkers indicating organ damage, including liver and kidney markers such as AST, ALT, and BUN. The use of YK-11 also appeared to enhance the removal of harmful bacteria from the mice's organs (source).

Lastly, it's worth noting that the study also examined the survival rate during sepsis, and mice treated with YK-11 had a higher likelihood of surviving up to the 72-hour mark. These treated mice showed little to no evidence of bacterial colonization in their vital organs.

Concentration
10mg/ml.

Half Life
6 – 10 hours.

DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary or domestic use. Please familiarize yourself with our DISCLAIMER before ordering.

Data Sheet

YK11 – Solution, 300mg (10mg/mL)