S-4 is a SARM more commonly known as Andarine, also referred to as Androxolutamide and GTx-007. In a fascinating study conducted by Gao et. Al,S-4 has been characterized as an androgen receptor agonist in orchidectomized rats, with the mechanism of action in the skeletal muscle, bone and pituitary gland.
S-4 Effects on Muscle Mass
Male rats were treated with either 3 mg/kg or 10 mg/kg S-4 over an 8 week period 12 weeks after castration. The study showed that both the 3 mg/kg dose and the 10 mg/kg dose were successful in restoring muscle mass and strength in the soleus muscle as well as muscle mass in the levator ani muscle comparable to that of intact male rats.
Treatment with S-4 also had a minimal impact on prostate and seminal vesicle weight by about 16-17%, but S-4 treatment had strong androgenic effects on prostate and seminal vesicles.
Furthermore, both the 3 mg/kg dose and the 10 mg/kg dose showed strong agonist activity in the pituitary gland by decreasing the plasma levels of both luteinizing hormone (LH) and follicle-stimulating hormone (LSH) in the castrated male rats (https http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039881/).
S-4 Effects on Bone Mineral Density
According to the study by Gao et. Al, treatment with S-4 for an 8 week course showed that there was a significant increase in bone mineral density in castrated male rats.
In a study conducted by Kearbey et. Al, female Sprague-Dawley rats were treated to see the effects of the SARM on the accelerated bone loss caused by oophorectomy. This study concluded that S-4 treatment maintained cortical content and overall bone mineral density, as well as increased bone strength while also decreasing overall body fat (https://pubmed.ncbi.nlm.nih.gov/17063395/).
In addition, the study conducted by Kearbey et Al. came to the general conclusion that treatment with S-4 has positive effects on skeletal muscle and bone. It was suggested that S-4 treatment could reduce fracture rates by increasing bone mineral density and strengthening bones, as well as strengthening skeletal muscles that reduce the likelihood of falls (https://pubmed.ncbi.nlm. nih.gov/17063395/ ).
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Andarine (S-4) – Powder, 1gr
|Application||Selective Androgen Receptor Modulator|
|Molar Mass||441.357 g/mol|
|Synonyms||Andarine, Andarin, S-4, S-40503, GTx-007|
|Solubility||Soluble in Ethanol, PEG400|
|Organoleptic Profile||Pale yellow fine powder|
|Terms||This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.|